Perbandingan Efektivitas antara Larutan Kumur Sodium Bikarbonat dan Nacl 0,9% dalam Mencegah Mukositis Oral pada Anak dengan Keganasan Hematologi yang Mendapat Kemoterapi
asaribu, Ayodhia Pitaloka P
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Background. Oral health care is recommended for preventing oral mucositis or the progression of oral mucositis itself, one of its component is mouthwash. Sodium bicarbonate (SB) or NaCl 0.9% is still recommended, which one is more effective remains to be established. Methods. In April until December 2018, we conducted a prospective open-label randomized trial comparison of 4 weeks oral health care with NaCl 0.9% and SB mouthwash in pediatric patients with hematologic malignancy undergoing chemotherapy. Oral mucositis was assessed with WHO Oral Toxicity Scale and all patients were confirmed not having oral mucositis before the intervention. The primary outcome was incidence of oral mucositis after 4 weeks of treatment. Result. Sixty-nine patients were included. There were no sigificant difference in patients characteristics at baseline between two groups. From Kaplan Meier curve, there was no significant difference between the two groups for mean onset of oral mucositis in SB (11.32 days, median 10 days) and NaCl 0.9% group (11.93 days, median 11 days) (P=0.763), but duration of oral mucositis was significantly different which in SB and NaCl 0.9% group were 4.86 days and 7.39 days respectively (P=0.004). At the end of this study, incidence of oral mucositis was 47.8% in SB group and 48% in NaCl 0.9% group (P=0.768). Oral hygiene became a risk factor for oral mucositis (P=0.001, RR 1.96, 95% CI 1.28-2.98). Conclusion. SB was not superior compared to NaCl 0.9% as mouthwash for preventing oral mucositis, but duration of oral mucositis was shorter in SB group.