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dc.contributor.advisorIlyas, Syafruddin
dc.contributor.advisorSabri, Emita
dc.contributor.authorRangkuti, Yufrina Namira
dc.date.accessioned2019-11-21T01:24:12Z
dc.date.available2019-11-21T01:24:12Z
dc.date.issued2017
dc.identifier.urihttp://repositori.usu.ac.id/handle/123456789/20821
dc.description49 Halamanen_US
dc.description.abstractDevelopment of contraceptive drug of combination methanolic bitter melon (Momordica charantia L.) seed extract and DMPA is still research. Depot medroxyprogesterone acetate contains steroid and anti-insulin which affects weight and blood glucose level of its acceptor, whereas bitter melon contains subtances that cause hypoglycemic. This study aims to determine the effect of combination of methanolic bitter melon seed extract and DMPA to pancreas histology and blood glucose level of male rabbits. This experiment using completely randomized design with five groups which were divided by treatment time. Each group had control group and treatment group. There were: treatment for 0 week (K0 and P0), 4 weeks (K1 and P1), 8 weeks (K2 and P2), 12 weeks (K3 and P3), and 16 weeks (K4 and P4). All rabbits which were grouped on treatment group had been induced by DMPA at first day of treatment, then they were given methanolic bitter melon seed extract 390 mg/1,5 kg body weight everyday during treatment time. The control groups had not been induced by DMPA but they were given aquadest 1 ml/day. For 12 weeks and 16 weeks groups, the rabbits which were included in both control and treatment groups were given the extract only for 8 weeks then they were being cared. Data research by giving combination methanolic bitter melon seed extract and DMPA in all groups don’t show any change of body weight and blood glucose level significantly so the result suggested that this drug is good and safe to be used. But its effect on pancreas histology couldn’t be known because its histology incision were not same as we needed.en_US
dc.description.abstractPengembangan obat kontrasepsi kombinasi ekstrak metanol biji pare (Momordica charantia L.) dan DMPA sedang marak dilakukan. Depot medroksiprogesteron asetat mengandung steroid dan anti insulin yang dapat mempengaruhi berat badan dan kadar gula darah penggunanya, sedangkan pare mengandung senyawa yang menyebabkan hipoglikemik. Penelitian ini bertujuan untuk mengkaji pengaruh kombinasi ekstrak metanol biji pare dan DMPA terhadap berat badan, histologi pankreas dan kadar gula darah kelinci jantan. Penelitian ini menggunakan Rancangan Acak Lengkap dengan 5 kelompok berdasarkan waktu pengamatan yang berbeda. Setiap kelompok memiliki kelompok kontrol dan perlakuan yaitu pengamatan selama 0 minggu (K0 dan P0), 4 minggu (K1 dan P1), 8 minggu (K2 dan P2), 12 minggu (K3 dan P3), dan 16 minggu (K4 dan P4). Seluruh kelinci kelompok perlakuan diinduksi DMPA pada hari pertama penelitian, selanjutnya diberi ekstrak metanol biji pare dengan dosis 390 mg/1,5 kgBB setiap hari selama waktu perlakuan. Kelompok kontrol tidak diinduksi DMPA namun diberi akuades 1 ml/hari. Untuk waktu pengamatan 12 minggu dan 16 minggu, baik kelinci kelompok kontrol maupun perlakuan hanya diberikan ekstrak selama 8 minggu kemudian dipelihara. Hasil penelitian menunjukkan bahwa pemberian kombinasi ekstrak metanol biji pare dan DMPA terhadap perubahan berat badan dan kadar gula darah pada seluruh kelompok tidak signifikan sehingga kombinasi ini kemungkinan berpotensi menjadi obat yang baik dan aman terhadap berat badan dan kadar gula darah. Sementara pengaruh dan keamanan terhadap histologi pankreas tidak diketahui karena sulit untuk mendapat sayatan pankreas sesuai seperti yang diharapkan.en_US
dc.language.isoiden_US
dc.publisherUniversitas Sumatera Utaraen_US
dc.subjectDMPAen_US
dc.subjectMomordica charantia L.en_US
dc.subjectKadar Gula Darahen_US
dc.subjectKelincien_US
dc.subjectKontrasepsien_US
dc.titlePengaruh Kombinasi Ekstrak Metanol Biji Pare (Momordica charantia L.) dan Depot Medroksiprogesteron Asetat (DMPA) terhadap Histologi Pankreas dan Kadar Gula Darah Kelinci Jantanen_US
dc.typeSkripsi Sarjanaen_US
dc.identifier.nimnipnik120805041


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