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dc.contributor.advisorZulfikar, Lubis
dc.contributor.advisorHanafie, Achsanuddin
dc.contributor.authorIndra, Rozi
dc.date.accessioned2020-07-20T02:31:21Z
dc.date.available2020-07-20T02:31:21Z
dc.date.issued2019
dc.identifier.urihttp://repositori.usu.ac.id/handle/123456789/26825
dc.description104 Halamanen_US
dc.description.abstractBackground Pentraxin 3 (PTX3) is an acute phase protein that represents the pentraxin subfamily and is expressed in various cells such as monocytes, endothelia cells, denritic cells and neutrophils during the inflammatory process. The sepsis patients there is dysregulation of the immune mechanism, where monocyte cells and macrophages will be activated which will then secrete proinflammatory cytokines such as TNFα, IL-1, IL-6, IL-8. To assess the severity of the disease based on the degree of organ dysfunction serially each time a score is used, namely Sequential Organ Failure Assessment (SOFA). The purpose of this study was to look at the relationship of PTX3 levels with SOFA scores in patients with sepsis. Method Prospective cohort study design. Thirty patients with sepsis who met the inclusion and exclusion criteria were included in this study. Samples obtained were measured by PTX3 levels and SOFA score calculations, which were analyzed by the Spearman correlation test. Differences between the 2 time groups were analyzed with the Willcoxon statistical test. Results and Discussion The significant relationship was obtained between PTX3 levels and SOFA scores on the first day (r = 0.779, p = 0.0001) and (r = 0.802, p = 0.0001) on the third day. Respiratory system dysfunction plays a role in increasing PTX3 levels. Conclusions Research shows an association between PTX3 levels and SOFA scores. PTX3 levels increase, SOFA scores increase, and vice versa. PTX3 values both the first day and the third day can be considered as alternative parameters to evaluate the deterioration of sepsis patients treated in the ICU.en_US
dc.description.abstractPendahuluan Pentraxin 3 (PTX3) adalah protein fase akut yang mewakili subfamili pentraxin dan diekspresikan dalam berbagai sel seperti monosit, sel endotel, sel denritik dan neutrofil selama proses inflamasi. Pada pasien sepsis terjadi disregulasi dari mekanisme imun, dimana sel-sel monosit dan makrofag akan teraktivasi yang selanjutnya akan mensekresikan sitokin-sitokin proinflamasi seperti TNFα, IL-1, IL-6, IL-8. Untuk menilai tingkat keparahan penyakit berdasarkan derajat disfungsi organ secara serial setiap waktu digunakan suatu skor yaitu Sequential Organ Failure Assessment (SOFA). Tujuan penelitian ini adalah untuk melihat hubungan kadar PTX3 dengan skor SOFA pada pasein sepsis. Metode Desain penelitian secara kohort prospektif. 30 pasien yang mengalami sepsis yang memenuhi kriteria inklusi dan ekslusi dilibatkan dalam penelitian ini. Sampel yang didapat dilakukan pengukuran kadar PTX3 dan perhitungan skor SOFA, yang dianalisa dengan uji korelasi Spearman. Perbedaan antara 2 kelompok waktu dianalisa dengan uji statistik Willcoxon. Hasil dan Pembahasan Didapatkan hubungan signifikan antara kadar PTX3 dan skor SOFA hari pertama (r=0.779, p=0.0001) dan (r=0.802, p=0.0001) pada hari ketiga. Disfungsi sistem respirasi sangat berperan pada peningkatan kadar PTX3. Kesimpulan Penelitian menunjukkan adanya hubungan antara kadar PTX3 dan skor SOFA. Semakin meningkat kadar PTX3 maka semakin meningkat pula skor SOFA, begitu juga sebaliknya. Nilai PTX3 baik hari pertama maupun hari ketiga dapat dipertimbangkan sebagai parameter alternatif untuk mengevaluasi adanya perburukan terhadap pasien sepsis yang dirawat di ICU.en_US
dc.language.isoiden_US
dc.publisherUniversitas Sumatera Utaraen_US
dc.subjectSepsisen_US
dc.subjectDisfungsi Organen_US
dc.subjectPentraxin3en_US
dc.subjectSkor SOFAen_US
dc.titleHubungan Kadar Pentraxin 3 dengan Skor Sequential Organ Failure Assessment (SOFA) pada Pasien Sepsis di RSUP H.Adam Malik Medanen_US
dc.typeTesis Magisteren_US
dc.identifier.nimnipnik157041070


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