Hubungan Kadar Serum Total Bilirubin dengan Kejadian Glaukoma pada Penderita Glaukoma Sudut Terbuka Primer

Abstract

Background: Primary Open Angle Glaucoma (POAG)is a complex group of diseases caused by various factors. According to recent studies, high intraocular pressure, genetic variations, blood vessel damage, oxidative stress, ametropia, and diabetes are risk factors. As an endogenous antioxidant, total bilirubin (TBIL) has been shown to have potential antioxidant activity and is inversely related to oxidative stress. Based on the increasing amount of evidence of increased oxidative and cytotoxic stress in glaucoma tissue, oxidatively modified proteins or oxidative stress-related products may be of great importance as glaucoma-related biomarkers. Objective: This study aims to determine the relationship between total serum bilirubin levels and the incidence of glaucoma in POAG sufferes at North Sumatra University hospital Materials and Methods: This research is an observational analytic study with a cross- sectional research design. Using a sample of 25 people at the Glaucoma Department of North Sumatra University hospital. This research will start from November 2023 until the number of samples is reached. Results: POAG >60 years old, there were 3 people with moderate degrees and 16 peoples with advanced degrees. The total mean bilirubin level in subject with medium POAG was 0.23 mg/dL. Using the Mann Whitney test, there was no significant difference between the levels of total bilirubin and POAG (p=0.131) in subjects aged 60 years. Conclusion: There is no relationship between between total serum bilirubin levels and the incidence of glaucoma in POAG