Efektivitas Ekstrak Air Daun Binahong (Anredera cordifolia (Ten)) dalam Menurunkan Inflamasi Gingiva pada Pasien Diabetes Melitus Tipe II

Abstract

Indonesia is among the top 10 countries with the highest prevalence of diabetes mellitus type II with the sharpest increase. Most of it can not diagnosed until have symptoms related to severe hyperglycemia. The most common symptom is mobility caused by gingival inflammation, it is can affect their nutrition, 95,5% of people in Indonesia admit that they have never been to the dentist for a year and most of them still use plants as medicine. This study aims to evaluate the effectiveness of binahong leaf water extract in reducing gingival inflammation on diabetes mellitus type II (DMTII) patients by reducing IL-17 levels and gingival index (GI).This research is a true experimental with pretestposttest control group design. The treatment was to provide binahong leaf extract mouthwash for seven days, gargled twice a day. 30 subjects were divided into five groups, 2 control groups (KN and KP) and 3 treatment groups who were given extract mouthwash with three different concentrations 12,5%, 25%, and 50% (EAB12,5, EAB25, and EAB50) then calculated the differences IL-17 levels and GI scores before and after treatment. IL-17 indicator taken from the subject's saliva and analyzed using ELISA. GI scores was evaluated for all teeth except third molars. There was no significant reduction on gingival inflammation in DMTII patients as calculated from the differences IL-17 levels before and after treatment (p=0,88). There was a significant difference in GI scores before and after treatment (p=0,04), the most significant reduction on gingival inflammation was in the EAB25 group compared with KN (p=0,02). This research proves that administration of binahong leaf water extract mouth rinses shows a reduction in gingival inflammation in DMTII patients as seen from the reduction in IL-17 levels and GI scores after treatment with binahong leaf water extract with three different concentrations.