Perbandingan Efektivitas Salmeterol/Fluticasone Propionate dan Formoterol Fumarate/Budesonide terhadap Tingkat Kontrol Asma pada Pasien Asma Persisten Sedang di Poliklinik Paru RS Prof. Chairuddin Panusunan Lubis Universitas Sumatera Utara

Abstract

Background: Asthma is a common chronic respiratory disease affecting 1-18% of the population in many countries. In Asia-Pacific, 7.6% of participants had controlled asthma, 30% uncontrolled, and 63% partially controlled. The high population partial control levels of asthma and the lack of data related to the level of control of asthma, especially in Prof. Chairuddin Panusunan Lubis Hospital Objective: The goal is to determine the effectiveness difference between Salmeterol/Fluticasone Propionate and Formoterol Fumarate Budesonide towards the level of asthma control with ACQ-GINA criteria. Methods: An analytic cohort retrospective study was performed by using 61 medical records subjects from January 1, 2017, to December 31, 2019. The subjects had moderate persistent asthma and received Fluticasone/Salmeterol and Budesonide/Formoterol therapy for at least three months. All data will be subjected to statistical testing by using the Fisher-exact test. Result: The statistical test showed no significant difference between the administration of both groups, Salmeterol/Fluticasone Propionate and Formoterol Fumarate/Budesonide, on the level of asthma control (p=0,057). Conclusion: Both Salmeterol/Fluticasone Propionate and Formoterol Fumarate/Budesonide combination have no difference in effectiveness in affecting the level of asthma control.