Perbandingan Nilai Parameter Inflamasi C-Reactive Protein, Neutrophil Lymphocyte Ratio, Platelet Lymphocyte Ratio Antara Scalp Block Ropivacaine 0.5% dan Dexmedetomidine Intravena pada Kraniotomi Tumor Otak

Abstract

Background : Craniotomy surgeries can increased inflammatory response in our body. Neuroendocrine system activated during surgery and anesthesia can release neuroendocrine and cytokine. Inflammatory response not only affected by the trauma of surgery, but also by anesthesia method. CRP, NLR and PLR as parameter of inflammation have strong relationship in inflammation during craniotomy. Scalp Block with ropivacaine, and dexmedetomidine can inhibit regulation of inflammation and can decreased the release of mediator inflammation include CRP,NLR and PLR. Objective : This study aimed to analyse CRP, NLR and PLR score in patient with Scalp Block with ropivacaine and dexmedetomidine intravenous in craniotomy patient. Methods : This study is experimental with two group posttest – only design that examines the differences in the values of inflammatory parameters neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP) between 0.5% Scalp Block ropivacaine and intravenous dexmedetomidine in brain tumor craniotomy. This study 36 samples were collected that met the inclusion criteria. The sample was divided into 2 groups, Group A was given 0.5% Scalp Block ropivacaine before surgery and Group B received intravenous Dexamethomidine. Then examined CRP, NLR and PLR levels before and 24 hours postoperative.. The data obtained from the research results were tested using SPSS Results : There was a significant difference increase in the change CRP, and PLR values in the group that received dexmedetomidine compared to the Scalp Block group with ropivacaine of 0.5%. Conclusion :Scalp Block ropivacaine 0.5% has better results compared to intravenous dexmedetomidine administration in suppressing the inflammatory response in postoperative tumor craniotomy patients.