Hubungan Ekspresi Immunohistokimia GATA3 dan TP53 pada Beberapa Subtipe Histopatologi Karsinoma Ovarium

Abstract

Background: Ovarian carcinoma is a cancer with high mortality in women and although comprehensive treatment with surgery and chemotherapy is at an advanced stage, survival rates are still low. GATA3 and p63 are predictors of some malignancies, but results vary in ovarian carcinoma. Objective: To examine correlation between immunohistochemical expression of GATA3 and p63 in patients with ovarian carcinoma with various histopathological subtypes. Materials and Methods: Cross sectional design is the method of this study conducted on slides of 28 ovarian carcinoma patients in several subtypes of hitopathology. Each slide was stained with hematoxylin and eosin (H&E) to assess hitopathological subtypes and stained with GATA3 and p63 antibodies.All clinicopathology data are taken from medical records/pathology archives. A logistic regression assay (p<0.005) was used to assess the association of GATA3 and TP53 immunohistochemical expression in several histopathological subtypes of ovarian carcinoma. Results: Among 28 specimens in patients with ovarian carcinoma, Cases was most prevalent in the age group >50-60 years (age range 58 years), history of nullipara parity, and most in the group of stage III ovarian malignancy. Positive immunohistochemical p53 expression is more prevalent in serous carcinoma. Positive GATA3 immunohistochemical expression is more prevalent in serous carcinoma. Conclusion: There is no significant relationship. Immunohistochemical expression of GATA3 and TP53 in some histopathological subtypes of ovarian carcinoma. However, immunohistochemical expression of GATA3 high p53 positive tends to be found in high-grade serous carcinoma.