| dc.description.abstract | Background: Kemloko fruit is a fruit that can be used as herbal medicine because it has been widely known for its nutritional content and function Kemloko (Phyllanthus emblica L.) or the people of North Sumatra call it "balakka". This plant in India has been used to treat cancer, diabetes, liver (heart), heart problems and anemia.
Objective: The purpose of this study was to determine the toxic effects after 28 days of administration of simplicia nanoparticles of kemloko fruit on the kidney and liver function of rats.
Method : The test animals were 60 rats consisting of 30 males and 30 females divided into 6 groups, namely 2 control groups and 4 treatment groups which were given simplicia nanoparticles powder at a dose of 100, 500, 1000 and satelite group 1000 mg/kgBW for 28 days, observed for 28 days. associated with mortality, body weight and toxic symptoms in rats. At the end of the test, the rats were dissected and observed levels of urea, creatinine, kidney relative weight, macroscopic and microscopic levels of kidney tissue. Data were analyzed statistically using one way ANOVA and continued with Tukey's test (p < 0.05).
Result: The results of the evaluation of the toxic effects of nanoparticle simplicia powder did not cause significant changes in body weight, urea and creatinine levels (p > 0.05). Simplicia nanoparticles at doses of 500 and 1000 mg/kgBB caused a significant increase in the relative weight of the kidneys and microscopic damage to kidney tissue in male and female rats.
Conclussion: Simplicia nanoparticle powder at a dose of 100 did not cause a toxic effect on the kidneys, while doses of 500 and 1000 mg/kgBB caused irreversible toxic effect on the kidneys. | en_US |
