| dc.description.abstract | Turmeric (Curcuma domestica Vahl.) is a traditional medicinal plant with
many benefits. Curcuminoid is a turmeric content that has activities such as
lowering blood sugar, antioxidant, anti-inflammatory, anti-carcinogenic. The
objective of this research was to evaluation the safety of curcuminoid VCO extract
which can cause damage to organisms.
Toxicity evaluation was carried out on curcuminoid VCO extract which was
extracted using the Microwave Assisted Extraction method with medium power
(270 Watt) for 10 minutes. Identification of curcuminoids was carried out using
TLC-Densitometry. Acute toxicity evaluation was carried out on female mice
observed for 14 days. Subchronic toxicity evaluation was carried out on female and
male mice for 90 days, plus 28 days of observation in the satellite group.
Examination includes organ macropathology, body weight, blood hematology,
clinical biochemistry, histopathology and signs of toxic symptoms.
The results of the study the acute toxicity evaluation was toxic at a dose of
2000 mg/KgBW. Toxic subchronic toxicity evaluation at a dose of 1000 mg/KgBW
and satellite 1000 mg/KgBW with symptoms of toxicity in the form of diarrhea,
hair changes, walking backwards, and walking using the stomach. and affects body
weight >10%. Macropathological observations showed accumulation of fatty liver
and lungs. Microscopic observation showed bleeding in the central vein, proximal
tubular bleeding, and dilation of Bowman's capsule, and there was death of the test
animal. There were significant differences in hematological and clinical blood
biochemistry tests (p<0.05) compared to the CMC Na 0.5% group and the VCO
group.
Based on research results, curcuminoid VCO extract is acutely toxic at a
dose of 2000 mg/KgBW. Subchronically toxic at a dose of 1000 mg/KgBW and is
irreversible, affecting body weight, hematological values, clinical blood
biochemistry, macropathology and organ histopathology. | en_US |
