Hubungan Grading Histopatologi dengan Usia Penderita Kanker Payudara Tipe Her2 di RSUP H. Adam Malik Periode Bulan Januari 2022 – Juni 2024

Abstract

Introduction. Breast cancer is a type of cancer that can cause death and is the most common in Indonesia. Nottingham grading (grade 1, grade 2, grade 3) in histopathological examination aims to assess tumor activity and prognosis. Other examination includes immunohistochemistry of biomarkers such as estrogen (ER), progesterone (PR), and HER2 receptors. Based on molecular subtypes, breast cancer is classified into luminal A, luminal B, HER2, and triple-negative. HER2- type breast cancer tends to be more invasive with a poor prognosis and susceptible to recurrence and metastasis. Objective. This study aims to determine the relationship between histopathological grading and age of patients with HER2-type breast cancer. Method. This is a non-experimental analytical research with crosssectional approach using the total sampling technique. Secondary data were taken from medical record of breast cancer inpatients at Adam Malik Hospital (January 2022 – June 2024) and analyzed using Fisher’s exact test. There were 492 cases of breast cancer inpatients, of which 195 patients had immunohistochemistry examination and 61 cases were HER2-type. A total of 54 patients who met inclusion criteria were taken as samples. Result and Discussion. HER2-type breast cancer identified was 31,3%. The most frequent characteristics included female, age ≥45 years, obesity as the nutritional status, and no family history. Poorly differentiated tumors were the most common (38,9%). Result of Fisher’s exact test showed a pvalue of 0,044 (p<0,05) and OR=0,134. Conclusion. There is a relationship between histopathological grading and age of patients with HER2-type breast cancer.