| dc.description.abstract | Introduction. Breast cancer is a type of cancer that can cause death and is the most
common in Indonesia. Nottingham grading (grade 1, grade 2, grade 3) in
histopathological examination aims to assess tumor activity and prognosis. Other
examination includes immunohistochemistry of biomarkers such as estrogen (ER),
progesterone (PR), and HER2 receptors. Based on molecular subtypes, breast
cancer is classified into luminal A, luminal B, HER2, and triple-negative. HER2-
type breast cancer tends to be more invasive with a poor prognosis and susceptible
to recurrence and metastasis. Objective. This study aims to determine the
relationship between histopathological grading and age of patients with HER2-type
breast cancer. Method. This is a non-experimental analytical research with crosssectional
approach using the total sampling technique. Secondary data were taken
from medical record of breast cancer inpatients at Adam Malik Hospital (January
2022 – June 2024) and analyzed using Fisher’s exact test. There were 492 cases of
breast cancer inpatients, of which 195 patients had immunohistochemistry
examination and 61 cases were HER2-type. A total of 54 patients who met inclusion
criteria were taken as samples. Result and Discussion. HER2-type breast cancer
identified was 31,3%. The most frequent characteristics included female, age ≥45
years, obesity as the nutritional status, and no family history. Poorly differentiated
tumors were the most common (38,9%). Result of Fisher’s exact test showed a pvalue
of 0,044 (p<0,05) and OR=0,134. Conclusion. There is a relationship
between histopathological grading and age of patients with HER2-type breast
cancer. | en_US |
