Korelasi Antara Platelet Distribution Width dan Mean Platelet Volume dengan Hematokrit pada Pasien Demam Berdarah Dengue di Rumah Sakit Prof. Dr. Chairuddin Panusunan Lubis Universitas Sumatera Utara

Abstract

Background. Dengue Hemorrhagic Fever (DHF) is a dengue virus (DENV) infection through the bite of an infected mosquito that manifests clinically in the form of high fever, headache, muscle pain, nausea, and rash. Research shows that several regions in Southeast Asia, including Indonesia, will experience an increase in the incidence of dengue infection in 2050 and 2080. Establishing a diagnosis of DHF can be assisted by laboratory tests of complete blood counts, including platelet distribution width (PDW), mean platelet volume (MPV), and hematocrit (Hct). Objective. This study aims to determine the correlation between platelet distribution width (PDW) and mean platelet volume (MPV) with hematocrit (Hct) in patients with Dengue Hemorrhagic Fever (DHF) at the Prof. dr. Chairuddin Panusunan Lubis Teaching Hospital, University of North Sumatra. Methods. This study was conducted with a cross-sectional design. The subjects of this study were 142 DHF patients aged > 17 years obtained from medical record data at the Prof. dr. Chairuddin Panusunan Lubis Hospital, University of North Sumatra. Statistical analysis using Pearson Correlation Test. Results and Discussion. In 142 study subjects, it was found that the majority of patients were in the age range of 18-39 years (83,8%) and were male (51.4%). The majority of patients had normal PDW values (85.2%), normal MPV values (91.5%), and normal hematocrit values (59.1%). The results of the Pearson's r correlation test between PDW and MPV with Hct obtained a p-value> 0.05. Conclusion. No significant correlation was found between PDW and MPV with Hct in DHF patients.