Perbandingan Glutathione dan Glutathione Peroxidase sebagai Biomarker Penuaan pada Saliva Lansia di Panti Jompo Yayasan Taman Bodhi Asri

Abstract

Comparison of Glutathione and Glutathione Peroxidase as Aging Biomarkers in the Saliva of Elderly Residents at Yayasan Taman Bodhi Asri Nursing Home xiv + 82 pages Aging is an unavoidable biological phenomenon. According to the World Health Organization, the global elderly population will increase from 1 billion in 2020 to 1.4 billion in 2030. Each individual experiences a heterogeneous aging process that cannot be easily tracked through chronological age alone, thus requiring biomarkers to measure biophysiological aging processes and represent the health status. This aging process can be explained by the oxidative stress theory, which involves an imbalance between reactive oxygen species and antioxidants. These antioxidants may include the glutathione system, which encompasses reduced glutathione (GSH), oxidized glutathione (GSSG), glutathione peroxidase (GPx1), and the GSH/GSSG ratio. The aim of this study was to compare salivary levels of GSH, GSSG, GPx1, and the GSH/GSSG ratio in young adults and elderly individuals. The method used in this study was cross-sectional with a purposive sampling technique. The total sample size was 48 individuals, divided into 24 young adults and 24 elderly individuals. Data analysis was conducted using the Mann-Whitney test, showing that the detected levels of GSH, GSSG, and the GSH/GSSG ratio in the saliva of young adults were higher than those in the elderly group, although the differences were not statistically significant (p > 0.05). In addition, the results indicated a significant difference in the levels of GPx1 detected in the saliva of the elderly group, which were higher than those in the young adult group (p = 0.001). The conclusion of this study is that GPx1 can be used as a salivary biomarker for aging.