Hubungan Antara Kadar Troponin dengan Kejadian Kardiovaskular Mayor pada Pasien Sindroma Koroner Akut di RSUP Haji Adam Malik

Abstract

Introduction : Coronary Artery Disease (CAD) is one of the leading cause of death globally. The most threatening manifestation of CAD is Acute Coronary Syndrome (ACS), that classified as Unstable Angina Pectoris (UAP), Non ST Elevation Myocardial Infarction (NSTEMI) and ST Elevation Myocardial Infarction (STEMI). ACS patients tend to have complication, which usually defined as Major Adverse Cardiovascular Events (MACE). MACE consists of heart failure, arrhythmia, stroke, and in-hospital mortality. Some factors have been researched to predict MACE in ACS, such as troponin level, which has been one of the modality to diagnose ACS. Furthermore, risk factors also play a role in increasing risk of MACE. Objective : This study aims to determine the association between troponin level and MACE in ACS patients at RSUP Haji Adam Malik. Method : This study uses an observational analytic method with cross sectional design and retrospective approach. The data used is a secondary data that meets the inclusion and exclusion criteria. Result : Among 190 patients, 170 patients (89,5%) were >45 years old and 114 patients (75,8%) were male. The most common type of ACS is NSTEMI, with 73 patients (38,4%). The most frequently risk factor is hypertension with 118 patients (62,1%) in it. Troponin level was increased in 131 patients (68,9%). There were 115 patients (60,5%) experiencing MACE and was dominated by heart failure, with 78 patients (41,1%). There was an association found between troponin level and MACE (p=0,000). There were no association found between age (p = 0,959), gender (p = 0,688), smoking (0,987), hypertension (p = 0,859), diabetes (p = 0,362), obesity (p = 0,095), and dyslipidemia (p = 0,545) with MACE in ACS patients. Conclusion : There was an association found between troponin level and MACE and there were no association found between the risk factors for CAD and MACE in ACS patients.