Hubungan Pemberian Kelasi Besi dengan Jumlah Ferritin pada Anak Penderita β-Thalassemia Mayor di RSUP Haji Adam Malik Medan Tahun 2021-2023

Abstract

Background: Children with β-Thalassemia major require lifelong blood transfusions to maintain their survival. Iron chelation therapy is crucial as it acts as an agent that can reduce serum ferritin levels. Therefore, adherence to iron chelation therapy must be closely monitored. Objective: This study aims to determine the correlation between iron chelation therapy and serum ferritin levels in children with β-Thalassemia major at RSUP Haji Adam Malik Medan. Methods: This research is an observational analytical study with a cross-sectional design. The study sample consisted of pediatric patients with β- Thalassemia major at RSUP Haji Adam Malik Medan from 2021-2023, using a total sampling technique. Results: Out of 50 patients, the majority of pediatric β-Thalassemia major patients at RSUP Haji Adam Malik in 2021-2023 were aged 11-15 years (42%), the highest number compared to other age groups. The use of iron chelation showed that Deferiprone (52%) was more frequently administered than Deferasirox (48%). The results of the correlation test using the Chi-Square test between ferritin levels before and after iron chelation therapy showed a p-value > 0.05. Conclusion: There is no significant correlation between the administration of iron chelation therapy and serum ferritin levels in children with β-Thalassemia major at RSUP Haji Adam Malik Medan.