Hubungan Polymorphonuclear Cell dan Mononuclear Cell terhadap Tingkat Keparahan Kanker Ovarium

Abstract

Introduction: Ovarian cancer is a gynecological cancer with a high mortality rate, mainly due to late diagnosis. Inflammatory factors, such as Polymorphonuclear Cells (PMN) and Mononuclear Cells (MN), are suspected to play an important role in determining disease severity, but data on this relationship are still limited, espe-cially in Indonesia. Objective: To investigate the relationship between PMN and MN levels and ovarian cancer severity, highlighting the inflammatory system's role in its pathogenesis. Methods: This was an analytical observational study with a cross-sectional design using retrospective data from January 2022 until August 2024 at Rumah Sakit Umum Pusat Haji Adam Malik, Medan. The inclusion criteria were ovarian cancer patients who were diagnosed histopathologically from stage I until IV at RSUP HAM Medan and underwent complete blood counts. Logistic regression analyzed the correlation between PMN, MN levels, and cancer severity. Results: Of 99 samples, with stage III was most common, as much as 44.4%. In PMN cells, 68.7% had neutrophilia, 57.6% had eosinopenia, and 94.9% had normal basophil levels. In MN, 73.7% had lymphocytosis and 72% had normal monocyte levels. Basophil and eosinophil levels significantly correlated with disease severity, suggesting their role in tumor progression via inflammatory mechanisms. Conclu-sion: Basophil and eosinophil levels can be potential biomarkers to help detect ovar-ian cancer early and determine therapeutic strategies. Further studies are needed to confirm these findings in a wider population and explore the mechanisms of the role of inflammatory components.