Perbandingan Efektivitas Penyembuhan Luka Bakar Derajat Dua Antara Pemberian Silver Sulfadiazine dan Gel Ekstrak Nigella Sativa pada Rattus Norvegicus

Abstract

Background: Second-degree burns are serious skin injuries that can lead to complications if not treated properly. Silver sulfadiazine (SSD) has long been used as the standard treatment for burn wounds due to its ability to inhibit infections. However, Nigella sativa (black cumin) also shows potential as an alternative therapy because it contains active compounds such as thymoquinone, saponin, and zinc, which have anti inflammatory, antioxidant, and immunomodulatory properties. Objective: This study aims to compare the effectiveness of second-degree burn wound healing between the application of silver sulfadiazine and Nigella sativa extract gel on white rats (Rattus norvegicus). Methods: This experimental study involved 30 rats divided into three groups: a control group, a treatment group with silver sulfadiazine, and a treatment group with Nigella sativa extract gel. Wound diameter and healing speed were observed and recorded over 28 days using calipers to measure wound diameter. Results: The results showed that the silver sulfadiazine group had the fastest average healing time (24 days), followed by the Nigella sativa extract gel group (26 days) and the negative control group (28 days). However, statistical analysis indicated no significant differences among the three groups (p > 0.05). In terms of burn wound contraction, no significant differences were observed for both 50% contraction (p = 0.409) and 100% contraction (p = 0.112). Nevertheless, Nigella sativa extract gel was found to be more effective than the other groups. Conclusion: This study demonstrates that Nigella sativa has potential as an alternative therapy for second-degree burns. With the anti inflammatory and antioxidant properties of thymoquinone and zinc, Nigella sativa gel offers a natural option with minimal side effects compared to silver sulfadiazine, particularly for patients seeking to avoid conventional medications.