| dc.description.abstract | Background: Second-degree burns are serious skin injuries that can lead to
complications if not treated properly. Silver sulfadiazine (SSD) has long been used as
the standard treatment for burn wounds due to its ability to inhibit infections. However,
Nigella sativa (black cumin) also shows potential as an alternative therapy because it
contains active compounds such as thymoquinone, saponin, and zinc, which have anti
inflammatory, antioxidant, and immunomodulatory properties. Objective: This study
aims to compare the effectiveness of second-degree burn wound healing between the
application of silver sulfadiazine and Nigella sativa extract gel on white rats (Rattus
norvegicus). Methods: This experimental study involved 30 rats divided into three
groups: a control group, a treatment group with silver sulfadiazine, and a treatment
group with Nigella sativa extract gel. Wound diameter and healing speed were observed
and recorded over 28 days using calipers to measure wound diameter. Results: The
results showed that the silver sulfadiazine group had the fastest average healing time
(24 days), followed by the Nigella sativa extract gel group (26 days) and the negative
control group (28 days). However, statistical analysis indicated no significant
differences among the three groups (p > 0.05). In terms of burn wound contraction, no
significant differences were observed for both 50% contraction (p = 0.409) and 100%
contraction (p = 0.112). Nevertheless, Nigella sativa extract gel was found to be more
effective than the other groups. Conclusion: This study demonstrates that Nigella
sativa has potential as an alternative therapy for second-degree burns. With the anti
inflammatory and antioxidant properties of thymoquinone and zinc, Nigella sativa gel
offers a natural option with minimal side effects compared to silver sulfadiazine,
particularly for patients seeking to avoid conventional medications. | en_US |
