Hubungan Penggunaan Analgesik NSAID (Nonsteroidal Anti-Inflammatory Drug) dengan Dispepsia pada Penderita Dismenorea di SMA Negeri 1 Medan

Abstract

Background. Globally, dysmenorrhea occurs in approximately 75% of women in reproductive years. NSAID (Nonsteroidal Anti-Inflammatory Drug) is the first line treatment for primary dysmenorrhea. NSAID can increase the risk of dyspepsia through the inhibition of COX enzyme, leading to the depletion of prostaglandin. Objective. To analyze the association between NSAID usage and dyspepsia incidence in female students of SMA Negeri 1 with dysmenorrhea. Method. This observational analytic study with cross-sectional design was conducted on female students of SMA Negeri 1 Medan. Data was collected using a questionnaire that gathers information on the intensity of dysmenorrhea, students’ behavior on treating dysmenorrhea, and the intensity of dyspepsia. The questions were adapted from working ability, location, intensity, days of pain, dysmenorrhea (WaLIDD) score, a questionnaire from former research on behavior in treating dysmenorrhea, and The Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ). Samples were acquired through stratified sampling with a total of 97 respondents. The data was analyzed using Chi Square to determine the association between both variables mentioned. Result. The p-value obtained was 0,393 (p > 0,05). Conclusion. There is no association between NSAID use and dyspepsia in female students of SMA Negeri 1 Medan with dysmenorrhea.