Perbandingan Sensitivitas Klotrimazol Krim 1% dan Larutan Asam Asetat 2% terhadap Isolat Jamur Pasien Otomikosis di RS Adam Malik dan RS Prof. Chairuddin P. Lubis

Abstract

Introduction. Otomycosis is a challenge in the medical field, because it requires long-term treatment and follow-up and has a high recurrence rate. In the administration of otomycosis therapy, there are various problems, such as the occurrence of resistance, difficulty in drug application, and requires a long period of time for management. Therefore, choosing the right treatment regimen is very important, so as to reduce the level of resistance caused by the fungus that causes otomycosis. Objective. To determine the comparison in sensitivity of 1% clotrimazole cream and 2% acetic acid solution to fungal isolates of otomycosis patients at Adam Malik Hospital and Prof. Chairuddin P. Lubis Hospital. Methods. This study used true experimental design in vitro with posttest only control group design. Sampling was done by total sampling method during the August-November period. In this study, 11 samples were obtained and tested on 3 treatment groups with repetition 3 times, so there were a total of 33 specimens studied. Results and Discussion. The results of statistical calculations with the Kruskal-Wallis test from 11 samples tested, obtained a p value <0.05 which indicates that there is a significant difference in the sensitivity of 1% clotrimazole cream and 2% acetic acid solution. Conclusion. The sensitivity of 1% clotrimazole cream and 2% acetic acid solution has a significant difference on fungal isolates of otomycosis patients.