Pengaruh Pengaplikasian Gel Buah Asam Jawa (Tamarindus Indica L.) terhadap Jumlah Sel Neutrofil pada Model Tikus Periodontitis

Abstract

Periodontitis is an inflammatory disease that causes progressive destruction of the periodontal tissues. Tamarind (Tamarindus indica L.) is a plant that has been widely used as a base for alternative medicine to treat various diseases. Tamarind contains various phytochemicals that are antibacterial, anti-inflammatory, antioxidant and others. Neutrophils are professional phagocytes that first appear during the first hours of inflammation. The purpose of this study was to determine the effect of the application of tamarind fruit gel (Tamarindus indica L.) with concentrations of 3.125%, 6.25% and 12.5% on the number of neutrophil cells in a rat model of periodontitis on day 3 and 7 and to determine the concentration of tamarind fruit gel which was effective in reducing the number of neutrophil cells in a rat periodontitis model. This research is a laboratory experimental study with a posttest only control group design. There were 32 periodontitis rat models which divided into 4 treatment groups (tamarind fruit gel 3.125%, 6.25%, 12.5% and placebo) and 2 days of observation (day 3 and 7). Data were analyzed by one way ANOVA test, post-hoc LSD test and t-independent. The results showed that there were significant differences between each group. Tamarind fruit gel group had lower neutrophil cell counts than the placebo gel group. The 12.5% concentration group had the lowest neutrophil cell count on day 3(9.62 ± 1.59) and day 7 (1.43 ± 0.55). This study showed that tamarind fruit gel can reduce the number of neutrophil cells in a periodontitis rat model.