Pengaruh Ekstrak Buah Asam Jawa(Tamarindus Indica L) terhadap Jumlah Sel Neutrofil pada Model Tikus Periodontitis

Abstract

Periodontitis is an inflammatory process that occurs in periodontal tissues caused by microorganisms. Tamarind (Tamarindus indica L) is a tropical plant native to East Africa. Tamarind has several contents that play a role in anti-inflammatories such as tannins, saponins, flavonoids and alkaloids. Neutrophils are white blood cells that first appear when the inflammatory process begins. The purpose of this study was to determine the effect of tamarind extract on the number of neutrophil cells in model periodontitis rats. This research is an experimental study with a post test control group design. In this study, 32 samples of periodontitis rat models were used which were divided into four treatment groups (tamarind fruit extract 3.125%, 6.25%, 12.5% and placebo and divided into two days of observation (3rd and 7 th day). Data were analyzed by one way ANOVA and t-independent test. The results showed that there was an influence of tamarind fruit extract (Tamarindus indica L) on the number of neutrophil cells in the rat model of periodontitis on the 3rd and 7th days. The group given tamarind fruit extract had a lower number of neutrophil cells compared to the placebo group. The tamarind fruit extract group with a concentration of 12.5% isthe concentration thatshows the lowest average number of neutrophil cells on day 3 (8.75±1.51) and 7th (1.56±0.31).