Daya Hambat Gel Ekstrak Andaliman (Zanthoxylum acanthopodium DC.) terhadap Pertumbuhan Bakteri Fusobacterium nucleatum secara In Vitro

Abstract

Andaliman contains alkaloid, flavonoid, glycoside, tannin, saponin, and triterpenoid compounds that have antibacterial abilities. Fusobacterium nucleatum is a bacterium that has an important role in periodontal disease as a bridge for early and late colony bacteria in plaque formation that can lead to periodontitis. Additional therapy in the form of local administration of antimicrobials in gel form can help in healing periodontal tissues after scaling and root planing. The purpose of this study was to determine the inhibitory effect of andaliman gel extract (Zanthoxylum acanthopodium DC.) against the growth of Fusobacterium nucleatum bacteria. The research method is a laboratory experiment with a post-test only design. Disc diffusion method was used as a sensitivity test of Fusobacterium nucleatum bacteria. The research sample used was Fusobacterium nucleatum ATCC® 25586™. Data analysis used was non-parametric analysis, namely Kruskal-Wallis test and Mann-Whitney test. The results showed that the diameter of the inhibition zone was 0 mm for andaliman gel extract in concentrations of 60%, 30%, 15%, 7.5%, and 3.75%. The conclusion of the study is that andaliman gel extract in concentrations of 60%, 30%, 15%, 7.5%, and 3.75% cannot inhibit the growth of Fusobacterium nucleatum ATCC® 25586™ bacteria.