| dc.description.abstract | Background: Sunflower seed oil has strong antioxidant activity so it has the
potential to be developed as an anti-aging preparation. The development of antiaging preparations containing sunflower seed oil in the form of nanocreams is
expected to increase the release of active substances thereby increasing the anti-aging
effect.
Methods: The study was conducted experimentally by comparing the results of the
formulation of sunflower seed oil nanocream preparations with the high-shear
stirring method consisting of 3 different concentrations, namely 2% (F2), 4% (F3),
and 6% (F4), with the formulation of sunflower seed oil cream (F1) and blank (F0).
Preparation evaluation tests determination of the type of emulsion in the form of
organoleptic tests, pH determination, dispersibility tests, homogeneity checks, of
preparations, determination of viscosity, centrifugation tests, determination of
particle size of preparations and evaluation of physical stability of preparations in
storage, irritation tests on volunteers and testing the effectiveness of anti-aging
preparations.
Results: The study produced a thick nanocream preparation, with a distinctive smell,
yellow color and had good evaluation test results, as well as good preparation quality
test results where the nanocream evaluation test met the requirements of pH around
(5.17-6.70), dispersion around (5.6-6.1 cm), homogeneous, had a type of oil
emulsion in water, met the requirements of viscosity test (2669.8-13519.1 mPas) and
centrifugation test. Nanocreams have an initial particle size of F2 329 nm, F3 252
nm and F4 100 nm, namely in the nanocream range of 20 to 500 nm. Each
formulation is stable at room temperature for 12 weeks, in a climatic chamber at 40
C, and in cycling tests. Nanocream preparations are non-irritating and have good
anti-aging effectiveness, where nanocreams containing 6% sunflower seed oil have
the best anti-aging effectiveness of all formulas.
Conclusion: Sunflower seed oil 2% (F2), 4% (F3) and 6% (F4) has the potential as
a nanocream preparation because it has good stability by meeting the requirements
of other creams and has anti-aging effectiveness, especially the 6% nanocream
preparation is the best compared to blanks and creams characterized by a decrease in
the number of pores, wrinkles and blemishes as well as an increase in facial moisture. | en_US |
