Hubungan Asam Laktat terhadap Mortalitas Pasien Sepsis Anak di Pediatric Intensive Care Unit (PICU) Rumah Sakit Umum Pusat Haji Adam Malik Medan

Abstract

Background: Pediatric sepsis is still a major health problem worldwide due to high mortality and morbidity. Increased lactate is used as a marker of tissue and cellular hypoperfusion in sepsis and septic shock. Lactate measurement is needed to predict mortality in pediatric sepsis patients. Objective: To determine the relationship between Lactate Levels and Mortality in Pediatric Sepsis at the Pediatric Intensive Care Unit of Haji Adam Malik General Hospital Methods: This was observational study of 101 pediatric sepsis patients who admitted to the PICU of Haji Adam Malik General Hospital, Medan from Januari 2023 - February 2024. Blood samples were collected in the first 24 hours after admission, and the lactate levels were determined. The statistical analysis used were the Chi square test, the unpaired t-test, the Mann-Whitney test. The area under the curve (AUC) of receiver operating characteristic (ROC) curve were used to determine the cut off value. Results: The mean lactate level was 27,15 mg/dL. The lactate levels was significantly associated with mortality (p<0,001). The optimal lactate cut off value was 18,1 mg/dL (sensitivity 68,1% and specificity 86,2%). The lactate serum achieved an AUC of 74,6% (p < 0,001) for predicting mortality. Conclusion: The lactate levels was significantly associated with mortality in pediatric sepsis. Keyword: Lactate, Pediatric Sepsis, Mortality, PICU