Faktor Risiko yang Mempengaruhi Resistensi Terhadap Karbapenem pada Infeksi Klebsiella Pneumoniae di RSUP Haji Adam Malik Medan

Abstract

Background: The high incidence of Klebsiella pneumoniae resistance limits the choice of antibiotics for this infection treatment, therefore Klebsiella pneumoniae infections are difficult to treat. Aims: This research aims to analyze risk factors and their correlation to the incidence of carbapenem antibiotic resistance in Klebsiella pneumoniae infection. Methods: This research is an analytical-observational research with a cross- sectional design and was carried out at Haji Adam Malik Hospital, Medan. The data obtained is secondary data taken from medical records. Descriptive statistical analysis was used to determine the frequency distribution of demographic data. Then proceed with inferential analysis where the Chi square test is used to analyze categorical data correlation. Multivariate logistic regression test is performed if a p value <0.25 is obtained in the bivariate test. Results: Risk factors for carbapenem resistance in Klebsiella pneumoniae infection at Haji Adam Malik Hospital Medan were history of hospital referrals (p value <0.001). Based on multivariate analysis, the factor that most influenced resistance namely a history of hospital referrals with RR = 14.840 (95% CI: 1.945-113.327). Conclusion: Hospital referral history is risk factor for carbapenem resistance in Klebsiella pneumoniae infection at Haji Adam Malik General Hospital Medan.