Korelasi Platelet Count, Mean Platelet Volume dan Platelet to Lymphocyte Ratio dengan Keparahan Gejala Orang dengan Skizofrenia

Abstract

Background: The exact pathophysiology of schizophrenia is not entirely comprehended, and there is growing interest in identifying accessible, cost-effective biomarkers for diagnosis and treatment. Platelet parameters have been suggested as potential biomarkers due to their involvement in serotonin pathways, inflammation, and oxidative stress. The aims of this study were to analyse the relationship between PLT, MPV, and PLR with symptom severity in ODS. Methods: This cross-sectional research was performed between June and November 2024, involved 48 individuals with schizophrenia. Platelet parameters (PLT, MPV, PDW, PCT, and PLR) were measured through a complete blood count (CBC), while to evaluate symptoms of schizophrenia was assessed using the Positive and Negative Syndrome Scale (PANSS). Correlation tests were used to analyse the relationships between platelet parameters and PANSS scores. Results: The study discovered that PLT (r = 0.348, p < 0.05) and PLR (r = 0.562, p < 0.05) were positively correlated with the severity of schizophrenia symptoms. Symptom severity was not significantly linked to MPV, PDW, and PCT. The participants' mean age was 32.69 years, and 81.2% of them being male and a median illness duration of 6 months. The mean PANSS score was 105.79, reflecting the severity of symptoms. Conclusion: Platelet parameters, particularly platelet count and PLR, show promise as cost-effective and accessible biomarkers for assessing the severity of schizophrenia symptoms. This finding suggests that platelets are a factor in the progression of schizophrenia, with a particular focus on the inflammation and serotonin pathways. To better understand the underlying mechanisms and verify their clinical utility in managing schizophrenia, more research is needed.