Uji Efek Tonikum Ekstrak Etanol Daun Kelor (Moringa Oleifera Lam) Pada Mencit Putih Jantan (Mus musculus)

Abstract

Background: Tonicum is an ingredient or mixture of ingredients that can strengthen the body or increase the body's energy of a person. This tonic effect is due to stimulation of the Central Nervous System (CNS). Previous research mentioned Moringa leaf drink has anti-tiredness activity. However, there is no research that examines the tonic activity of moringa leaves. Objective: To test the tonic effect of moringa leaf ethanol extract on MSG-induced male white mice and the best dose of moringa leaf ethanol extract in providing a tonic effect on MSG-induced male white mice. Method: This study was conducted experimentally using 5 groups namely K(-) (Na-CMC 0.5%), K(+) (Caffeine 13 mg/kg BW), (EEDK doses of 100, 200, and 400 mg/kg BW). Each group consisted of 5 mice that were induced with a dose of MSG 4000 mg/kgBB and then given the test preparation for 14 days, motor coordination assessment was carried out using the rotarod performance test method on day 15. Results: The average percentage increase of tonic effect in K(-), K(+), P1, P2, P3 were -68.32±1.18; 152.44±0.89; 11.13±0.78; 59.44±1.48; 92.18±1.09. Data analysis was normally distributed and homogeneous. One way anova test obtained a significance value of p (0.000) <0.05. Post hoc test has a significant difference (p < 0.05) between K(-) with K(+), K(+) with P1, K(+) with P2, K(+) with P3. Conclusion: Moringa leaf ethanol extract (Moringa oleifera) has a tonic effect on male white mice (Mus musculus) induced by MSG with an optimum dose of (400mg/kgBB).