Ekstrak Bawang Putih Tunggal yang Difermentasi (Allium sativum L. var. solo garlic) terhadap Respon Koordinasi Motorik pada Tikus

Abstract

Background: Solo black garlic is a processed product of solo garlic obtained through fermentation. This process enhances the content of bioactive compounds, one of which is s-allyl cysteine. As a stimulant, solo garlic can influence the function of the central nervous system and improve motor coordination disorders caused by excessive monosodium glutamate (MSG) induction. Several previous studies have shown that solo garlic has stimulant effects however no studies have yet examined the effect of solo black garlic extract (EBHT) on motor coordination disorders. Objective: To determine whether the administration of EBHT can improve motor coordination response in rats induced with MSG and to identify the most effective dose in enhancing motor coordination response in rats induced with MSG. Method: This study was conducted experimentally using 5 groups: K(-) (Na-CMC 0.5%), K(+) (Caffeine 9 mg/kg body weight), EBHT 50, 75, 100 mg/kg body weight. Each group consisted of 5 rats that were induced with MSG at a dose of 4000 mg/kg body weight, followed by the administration of the test preparation for 14 days. Motor coordination assessment on the 15th day was carried out using the rotarod performance test method. Results: The average percentage increase in stimulant effects for K(-), K(+), EBHT 50, 75, and 100 mg/kg body weight were -80.61±2.35; 52.40±1.96; 23.47±1.42; 35.66±0.97; 40.48±1.28, respectively. The data obtained were normally distributed and homogeneous. One Way Anova test showed a significance value of p (0.000) < 0.05. Post Hoc test revealed significant differences (p < 0.05) between K(-) and K(+), K(+) and EBHT 50 mg/kg body weight, K(+) and EBHT 75 mg/kg body weight, and K(+) and EBHT 100 mg/kg body weight. Conclusion: The administration of EBHT can improve the motor coordination response in rats induced with MSG, with the most effective dose being 100 mg/kg body weight.