Pengaruh Pemberian Curcumin Terhadap Perbaikan Gangguan Penghidu Pada Pasien Penyakit Ginjal Kronik Hemodialisis Reguler Ditinjau Dari Kadar Indoxyl Sulfate (IS) Dan Pemeriksaan Sniffin’ Stick Test di RS Adam Malik

Abstract

Introduction:Olfactory dysfunction in chronic kidney disease patients indicates neurological disorders in uremic conditions that increase in prevalence along with the severity of kidney disease. Indoxyl sulfate is a uremic toxin known to contribute to the worsening of kidney disease. Curcumin plays an important role in preventing disease pathogenesis due to its ability as an effective scavenger for ROS or reactive oxygen species; curcumin also promotes the growth and viability of olfactory ensheathing cells in normal and hypoxic conditions. Method: This study is preliminary research because there is still very rare research on this topic, conducted on 48 patients with stage 5 chronic kidney disease on regular hemodialysis who were divided into three groups: control group, 500 mg curcumin, and 1000 mg curcumin. They were given curcumin extract for 12 weeks. Plasma indoxyl sulfate levels and then their olfactory function was checked. Bivariate and multivariate tests were conducted to compare the results before and after treatment. Results: There were significant differences in olfactory discrimination delta (p=0.001) and olfactory function delta (p=0.002) in the 1000 mg curcumin group and the 500 mg curcumin group.There were significant differences in olfactory identification before and aftertreatment in the 1000 mg curcumin olfactory group (p=0.006), delta identification (p=0.618), as well as significant differences in IS levels in the 500 mg curcumin group (p=0.008) and the control group (p=0.019); delta IS level (p=0.870). There was no significant difference in olfactory threshold in the three study groups (p=0.636). Conclusion: Olfactory dysfunction in chronic kidney disease patients improved with the administration of curcumin, and no worsening of indoxyl sulfate levels was found, indicating that curcumin can stabilize the toxin.