Formulasi Solid Self-Emulsifying Drug Delivery System Ibuprofen, Uji Efek Antiinflamasi, dan Uji Pengurangan Efek Iritasi terhadap Lambung pada Tikus

Abstract

Background: Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID). One of the disadvantages of NSAIDs can cause stomach ulcers. Thus, ibuprofen Solid SEDDS preparation was formulated to reduce the gastric irritating effect of NSAID class drugs and a comparison was made with Liquid SEDDS. Objective: To formulate, characterize, test the gastric irritation reduction and antiinflammatory effects of ibuprofen Solid SEDDS preparation in rats. Methods: Formulation of ibuprofen Solid SEDDS preparation by adsorbtion to solid carrier method with adsorbent variation (aerosil, talcum, lactose). Then the best Solid SEDDS formula was taken to compare characterization with Liquid SEDDS including organoleptic, pH, particle size, zeta potential, content and dissolution. Furthermore, the stability test of the preparation includes organoleptic, drug content, particle size, pH and dissolution. Continued testing of anti inflammatory effects, and gastric irritation effects using rats consisting of 4 groups. Results: From the results of the study, aerosil was found to be the best adsorbent for the Solid SEDDS formula. From the characterization results obtained particle size of 461.91 ± 19.55, content of 104.82 ± 5.28%, and zeta potential of -38.1 ± 0.17 mV. From the dissolution results of Solid SEDDS at the 60th minute, it reached 88.25% in phosphate buffer pH 7.2. In testing the anti-inflammatory effect, Solid SEDDS produced the same effect as ibuprofen Liquid SEDDS, while for testing the gastric irritation effect, ibuprofen Solid SEDDS proved to reduce the gastric irritation effect significantly compared to ibuprofen suspension but produced the same effect as Liquid SEDDS. Conclusion: Based on the results of the research, it can be concluded that ibuprofen can be formulated in Solid SEDDS dosage form by adsorbtion to solid carrier method, Solid SEDDS ibuprofen has the same anti-inflammatory effect and gastric irritation reduction effect as Liquid SEDDS but significantly different from ibuprofen suspension.