Formulasi dan Evaluasi Sediaan Hidrogel Anti-Aging Ekstrak Etanol Daun Gagatan Harimau (Ampelocissus thyrsiflora (Blume) Planch.)

Abstract

Background: Premature aging is a condition in which the skin ages ahead of its time. Prevention and reduction of the effects of premature aging can be done by utilizing the properties of antioxidants. Gagatan harimau (Ampelocissus thyrsiflora (Blume) Planch.) is one of the plants that has antioxidant activity. The content of flavonoids, alkaloids, saponins, tannins and steroids in gagatan harimau has antioxidant activity that has the potential as an anti-aging active ingredient formulated in hydrogel dosage form. Objective: To determine the anti-aging effectiveness of ethanol extract of gagatan harimau leaves formulated in hydrogel dosage form. Methods: This study was conducted with experimental method including the stages of sample collection, preparation of simplisia and ethanol extract of gagatan harimau leaves (EEDGH), characterization, phytochemical screening, preparation of hydrogel preparations formula F0 (base), F1 (EEDGH 2%), F2 (EEDGH 4%) and F3 (EEDGH 6%), evaluation of hydrogel preparations, stability test and cycling test of hydrogel preparations, irritation test and anti-aging effectiveness test with skin analyzer device. Results: Phytochemical screening of simplisia and EEDGH showed the presence of alkaloids, flavonoids, glycosides, saponins, steroids and tannins. The evaluation results of hydrogel preparations are homogeneous, pH 5.84-6.10, spreadability 5-7 cm, viscosity 9672.33-12015.33 cPs, stable in storage for 3 months at room temperature and in the cycling test, does not irritate the skin and shows anti-aging effectiveness characterized by an increase in the percentage of recovery in moisture parameters, pore diameter, number of spots and number of wrinkles. Conclusion: Hydrogel preparation of ethanol extract of gagatan harimau leaf has anti-aging activity with an increase in the percentage of recovery of the four anti- aging parameters namely moisture, pore diameter, number of spots and number of wrinkles. The hydrogel preparation with the best anti-aging effectiveness is F3 (EEDGH 6%) with percentage recovery of moisture (74%), pore diameter (67%), number of blemishes (63%) and number of wrinkles (64%).