Ekspresi Kadar VCAM-1 (Vascular Cell Adhesion Molecule 1) pada Pasien PASD (Placenta Accreta Spectrum Disorder) dibandingkan Pasien Dengan Kehamilan Normal Di Rumah Sakit Adam Malik Dan Rumah Sakit Jejaring

Abstract

Introduction: Placenta accreta spectrum disorder (PASD) can cause long-term adverse effects such as fertility problems and risk of maternal mortality during labour. Vascular cell adhesion molecule-1 (VCAM-1) is a cell adhesion molecule commonly found in endothelial cells, macrophage tissue, and placental trophoblastic cells and is associated with PASD. Methods: This study was an observational analytic study with the aim of assessing the association of pre-natal serum VCAM-1 levels with the mean incidence and severity of PASD at Adam Malik Hospital and University of North Sumatra (USU) Network Hospital in Medan, Indonesia. Results: The mean VCAM-1 level was found to be higher (p = 0.01) in the group with PAS (398.77 ± 77.36) compared to pregnancy (293.13 ± 161.93) The mean VCAM-1 level with the highest level was in the precreta placenta group 518.21 ± 150.70 (p = 0.007). The sensitivity and specificity values of VCAM-1 as a predictor of PASD with a cut-off of 307 were 71% and 65.6%. Conclusion: VCAM-1 levels can be one of the predictors of PASD in pregnant women.