| dc.description.abstract | The Effect of 5% Andaliman Fruit Extract Cream (Zanthoxylum
acanthopodium DC.) on Keloid Lesion Improvement
Ira Mendrofa, Imam Budi Putra, Nova Zairina Lubis
Department of Dermatology and Venereology, Faculty of Medicine,
Universitas Sumatera Utara, Medan, Indonesia
ABSTRACT
Background:Keloids are an abnormal wound healing process characterized by
benign fibroblast proliferation that can result in scar tissue extending beyond the
original wound edges. Andaliman (Zanthoxylum acanthopodium DC.) is a plant
found in Indonesian forests, particularly in North Sumatra. The andaliman fruit
has antiinflammatory and wound healing effects that may be beneficial for keloid
therapy.
Objective: To determine the effect of 5% andaliman fruit extract cream
(Zanthoxylum acanthopodium DC.) on the improvement of keloid lesions.
Subjects and Methods: This pre-experimental clinical trial was designed as a
pretest-posttest study involving 30 subjects with keloids. Diagnosis was
established through anamnesis and clinical examination. Evaluation was done
using the Vancouver Scar Scale (VSS) and measuring the lesion area before and
after applying the 5% andaliman fruit extract cream at weeks 0, 4, 8, and 12. Side
effects were recorded during the study, and satisfaction levels were assessed at the
end of the study. Friedman tests and post hoc test were conducted to examine
differences before and after treatment, with a p-value <0.05 considered
significant.
Results: There was a statistically significant decrease in VSS and lesion area in
subjects with keloid lesions after 12 weeks of applying the 5% andaliman fruit
extract cream. No subjects experienced side effects, and all were satisfied with the
application of the cream.
Conclusion: The use of 5% andaliman fruit extract (Zanthoxylum acanthopodium
DC.) cream can improve keloid lesions without side effects and provides a high
level of satisfaction.
Keywords: keloid, andaliman, Zanthoxylum acanthopodium DC. | en_US |
