| dc.description.abstract | Background: Ibuprofen is a medication that can cause stomach irritation through
a local mechanism. Sodium Alginate has a protective effect on the stomach by
forming a gel that helps protect the stomach lining.
Objective: This study aims to formulate and test the stomach irritation prevention
effects of an ibuprofen suspension containing sodium alginate and xanthan gum in
rats.
Method: A study was conducted to test four different formulations: ibuprofen
suspension containing xanthan gum with sodium alginate, ibuprofen suspension
with xanthan gum, ibuprofen suspension with sodium alginate, and a 1% sodium
alginate solution. Physical characterization was then performed, including
organoleptic evaluation, content determination, particle size of the formulation, zeta
potential, viscosity, pH, specific gravity, dissolution, sedimentation volume, and
stability. The effects on gastric irritation were tested both macroscopically and
microscopically, and the anti-inflammatory effects were evaluated using the paw
edema method with male Wistar rats as test subjects.
Results: The results obtained in terms of characteristics and stability, ibuprofen
suspension containing xanthan gum and sodium alginate has a good dissolution rate
and has a good sedimentation volume because there is no precipitation. Ibuprofen
suspension containing xanthan gum and sodium alginate can reduce gastric
irritation which is the same as administration 30 minutes before administration of
ibuprofen suspension and has the same anti-inflammatory effect as ibuprofen
suspension with xanthan gum.
Conclusion: It can be concluded that, physically, the ibuprofen suspension
containing xanthan gum and sodium alginate is the best formulation. In the gastric
irritation prevention test, the ibuprofen suspension with xanthan gum and sodium
alginate was able to prevent stomach irritation. In the anti-inflammatory test, the
ibuprofen suspension with xanthan gum and sodium alginate showed the best antiinflammatory
effect. | en_US |
