Pengaruh Pemberian Ekstrak Jamur Tiram (Pleurotus ostreatus) terhadap Histologi Ginjal Tikus (Rattus norvegicus) Model Hiperlipidemia

Abstract

Hyperlipidemia can cause impaired kidney function. Oyster mushrooms (Pleurotus ostreatus) contain lovastatin which is able to reduce cholesterol levels in the blood. This study aims to determine the effect of oyster mushroom extract administration on urea, creatinine and uric acid levels in the blood, morphology and histology of the kidneys of rats (Rattus norvegicus) hyperlipidemia models. This study used a Completely Randomized Design (RAL) with 6 treatment groups and 4 replicates. The treatment group consisted of K- which was a group of normal rats, K+ namely rats fed high fat and a treatment group that was fed with high fat with simvastatin treatment and oyster mushroom extract with doses of 150, 300 and 450 mg/KgBW. The results showed that the treatment with oyster mushroom extract had no effect on urea levels, creatinine and blood uric acid (p>0.05), but at a dose of 450 mg/KgBW was able to improve kidney morphology including color, texture and weight as well kidney histology including glomeric diameter, proximal tubule wall thickness and necrosis (p<0.05) that occurs due to high-fat feeding.