Pengaruh Ekstrak Etanol Daun Kelor (Moringa oleifera) Pada Histologi Ginjal Tikus (Rattus norvegicus L.) Model Kanker Payudara

Abstract

Moringa leaves (Moringa oleifera) have potential as a medicine to maintain renal safety activities which act as an anti-inflammatory, antioxidant and anticancer properties. This study seeks to assess the impact of ethanol extract from moringa leaves on the morphology and histology of the kidneys in rats (Rattus norvegicus L.) with breast cancer models generated by 7,12-Dimethylbenz[a]Anthracene (DMBA). This study comprised of six treatments and four replications utilizing a Completely Randomized Design (CRD). The treatments included normal controls (untreated rats), negative controls (rats induced with DMBA), positive controls (rats administered doxorubicin), and treatments with ethanol extract of moringa leaves, designated as P1, P2, and P3, at doses of 100, 200, and 300 mg/kg BW, respectively. Observations made included the color, the shape, the weight, and the histology of the rat kidneys, including glomerular diameter, proximal tubules, and necrosis. The analysis results indicate the administration of ethanol extract from Moringa oleifera leaves do not influence the morphology of kidney color and shape. The observations of the kidney weight, the morphology, and the histology reveal significant changes (p< 0.05) between the negative control group and all groups treated with moringa leaf extract. A dosage of 200 mg/kg BW of Moringa oleifera is optimum dosage since it enhances kidney weight shape, reduces glomerular width, diminishes proximal tubule constriction, and decreases renal necrosis.