| dc.description.abstract | Background: Melasma is a condition of acquired hypermelanosis, in the form of
symmetrical macules, light brown to dark brown generally in areas exposed to
ultraviolet (UV) light with a predilection on the cheeks, forehead, upper lip area,
nose and chin. The main goal of melasma therapy is to completely disguise or
eliminate hyperpigmentation, reduce the size of the lesion, and prevent recurrence.
An in vitro study on avocado seed extract showed its effect as a potent tyrosinase
inhibitor, so that natural depigmenting agents from herbal ingredients such as
avocado seed extract may provide opportunities as an effective method in treating
melasma.
Objective: To determine the effect of 1% avocado seed extract nanoemulgel
(Persea americana Mill.) on melasma
Methods: Pre-experimental clinical trial research with a pretest-posttest design on
30 melasma subjects. Diagnosis is made through history and clinical examination.
The assessment was conducted using the Melasma Area Severity Index (MASI),
mexameter and skin analyzer which were assessed before and after administration
of 1% avocado seed extract nanoemulgel (Persea americana Mill.). Evaluation
was conducted every 2 weeks, side effects were observed and noted during the
study. Friedman test was carried out to see the differences before and after
treatment with a p value <0.05 considered significant.
Result: The characteristics of the study subjects showed that the majority were
aged 40-50 years (46.67%) with an average age of 45.03±4.63. The application of
1% avocado seed extract nanoemulgel showed a significant difference in MASI
scores, melanin index, RGB spot, and UV pigmentation (p<0.05). In this study, no
side effects were found after the application of 1% avocado seed extract
nanoemulgel.
Conclusion: The application of 1% nanoemulgel of avocado seed extract (Persea
americana Mill.) can improve the appearance of melasma
Keywords: melasma, melasma area severity index, melanin index, avocado seed,
Persea americana Mill. | en_US |
