Perbandingan Skor Visual Analog Scale dan Numeric Rating Scale pada Pemberian Pregabalin 50 Mg dengan Pregabalin 75 Mg Sebagai Adjuvan pada Pasien Pasca Operasi Tulang Belakang

Abstract

Background: Postoperative pain following spinal surgery is a major patient complaint that can affect quality of life and prolong hospital stays. Pregabalin, as an adjuvant analgesic, has shown effectiveness in managing neuropathic pain; however, its optimal dosage remains debatable. Objective: To compare the effectiveness of pregabalin 50 mg versus 75 mg in reducing postoperative spinal surgery pain, measured by the Visual Analog Scale (VAS) and the Numeric Rating Scale (NRS). Methods: This study employed a double-blind randomized clinical trial design. Subjects were postoperative spinal surgery patients who met inclusion and exclusion criteria, randomly assigned into two groups. Group A received pregabalin 50 mg every 8 hours and fentanyl 0.25 mcg/kg/hour, while Group B received pregabalin 75 mg every 8 hours with the same fentanyl dose. Pain was assessed using the VAS and NRS at 0, 6, 12, and 24 hours postoperatively. Data analysis was performed using T-Independent or Kruskal-Wallis tests depending on data distribution. Results: Administration of 75 mg pregabalin showed a significantly greater reduction in VAS and NRS scores at all measured time points compared to 50 mg pregabalin. The differences were statistically significant. Conclusion: Pregabalin 75 mg is more effective than 50 mg in reducing postoperative pain following spinal surgery, based on both VAS and NRS scores. These findings support its use as part of multimodal analgesia in spinal postoperative pain management.