Pengaruh Krim Nanopartikel Ekstrak Kelopak Bunga Rosela (Hibiscus sabdariffa L.) 5% terhadap Selulit

Abstract

Background: Cellulite is a topographic change in the skin characterized by a wavy appearance or a texture resembling orange peel, cottage cheese, or mattress-like patterns. No standard therapy has been established for the treatment of cellulite. The objectives of cellulite therapy are to enhance microvascularization, stimulate lipolysis, improve the structure of dermal and subcutaneous tissues, and prevent free radical damage. Roselle petals contain various active compounds such as anthocyanins, ascorbic acid, hibiscus acid, and flavonols, which contribute to the improvement of cellulite through mechanisms that enhance microcirculation, provide anti-inflammatory and antioxidant effects, stimulate lipolysis, and support collagen synthesis. Objective: To determine the effect of a 5% nanoparticle cream containing roselle petal extract (Hibiscus sabdariffa L.) on cellulite. Methods: A Quasi Experimental clinical trial was conducted using a pretest posttest design involving 30 subjects with cellulite. Diagnosis was established through anamnesis and clinical examination. Evaluation was performed using the Photonumeric Cellulite Severity Scale (PCSS), assessed at weeks 0, 2, 4, 6, and 8 following the application of a 5% nanoparticle cream containing roselle petal extract (Hibiscus sabdariffa L.). Side effects and satisfaction levels were recorded throughout the study. The Friedman test was used to analyze differences before and after treatment, with a p-value <0.05 considered statistically significant. Result: The characteristics of the study subjects showed that the majority were aged between 26–35 years (46.67%) and most had a family history of cellulite, predominantly from their mothers (63.3%). There was a statistically significant reduction in the severity of cellulite (p<0.05) after 8 weeks of cream application. No side effects were reported, and all subjects expressed satisfaction based on their level of satisfaction. Conclusion: The application of a 5% nanoparticle cream containing roselle petal extract (Hibiscus sabdariffa L.) can improve the appearance of cellulite. Keywords: Cellulite, Hibiscus sabdariffa L., Photonumeric Cellulite Severity Scale.