Hubungan Anterior Chamber Depth (ACD), Axial Length (AL), dan Lens Thickness (LT) dengan Endothelin-1 pada Remaja Penderita Miopia di Rumah Sakit Prof. Chairuddin Panusunan Lubis Universitas Sumatera Utara

Abstract

Introduction: Myopia, a prevalent refractive error among adolescents, is influenced by ocular anatomical factors such as anterior chamber depth (ACD), axial length (AL), and lens thickness (LT). Additionally, endothelin-1 (ET-1), a vasoconstrictive peptide, has been implicated in vascular regulation within the eye. This study aims to evaluate the relationship between ACD, AL, and LT with ET-1 levels in adolescent myopia patients at RS Prof. Chairuddin Panusunan Lubis. Methods: This cross-sectional study included 60 adolescent patients aged 14–19 years with varying degrees of myopia (-0.5 D or greater) between August 2024 and February 2025. Biometric measurements (ACD, AL, LT) were obtained using Ascan ultrasonography. Serum ET-1 levels were quantified using ELISA. Statistical correlations between biometric parameters and ET-1 levels were analyzed. Results: The mean AL was 25.45 ± 1.26 mm (OD) and 24.98 ± 2.19 mm (OS), with longer AL observed in high myopia (p < 0.001). The mean ACD was 3.5 ± 0.54 mm (OD) and 3.4 ± 0.37 mm (OS), with no significant variations between myopia severity levels (p > 0.05). LT showed significant differences across severity groups (p = 0.047). ET-1 levels were inversely correlated with AL (r = - 0.271, p = 0.036), with no significant associations observed for ACD or LT. Conclusion: This study highlights a significant inverse correlation between AL and ET-1 levels in adolescent myopia patients, suggesting potential vascular involvement in myopia progression.