Pengaruh Nanoserum Ekstrak Rumput Laut (Eucheuma cottonii) 5% terhadap Penuaan Kulit Wajah

Abstract

Background: Skin aging is a biological mechanism influenced by a combination of endogenous or intrinsic factors and exogenous or extrinsic factors. Eucheuma cottonii seaweed comes from cultivation in the South Coast. Seaweed is referred to as a source of bioactive compounds due to its ability to produce a wide variety of organic compounds characterized by broad biological activities as antioxidants, immunostimulants, and antibacterials. Objective: To aim the effect of seaweed extract nanoserum (Eucheuma cottonit) 5% on facial skin aging. ERS Methods: This pre-experimental clinical trial study was conducted with a pretest- posttest design on 40 subjects with facial skin aging. Diagnosis was established through history taking and clinical, evaluation using Dermoscopic photoaging scale (DPAS) and skin analyzer before and after administration of seaweed extract nanoserum (Eucheuma cottonii) 5% at week 0, 2, 4, 6, 8. Side effects were recorded during the study and satisfaction level was assessed at the end of the study period. Repeated ANOVA and Friedman tests were performed to see the difference before and after treatment with p value <0.05 considered significant. Results: There was a statistically significant decrease in DPAS scores in subjects with aging facial skin after 8 weeks of seaweed extract nanoserum (Eucheuma cottoni) 5% administration (p<0,001). Based on the examination using a skin analyzer during the 8-week seaweed extract nanoserum (Eucheuma cottonit) 5%, there was a significant improvement in the mean values of hyperpigmentation spots, wrinkles, roughness, UV moisture, and UV pigmentation (p<0.001), while UV damage there was an improvement, but not significant (p=0.836). All subjects did not experience any side effects and were satisfied with the administration of seaweed extract nanoserum 5%. Conclusion: The use of seaweed extract nanoserum (Eucheuma cottoni) 5% can improve the appearance of aging facial skin without side effects and has a good level of satisfaction.