Pengaruh Ekstrak Etanol Lumut Hati Marchantia paleacea Bertol. Pada Jaringan Payudara Tikus (Rattus norvegicus L.) Setelah Diinduksi 7,12 Dimetilbenz(α)anthracene (DMBA)

Abstract

nticancer agent, It possesses antiproliferative properties, and may influence the growth of mammary nodules. This study seeks to assess the impact of Marchantia paleacea Bertol methanol extract on the breast tissue of rats (Rattus norvegicus L.) induced by 7,12-dimethylbenz(a)anthracene (DMBA). This research employed a Completely Randomized Design (CRD). Twenty-four rats were allocated into various treatment groups, comprising a negative control group (DMBA without treatment); a positive control group (doxorubicin administration), and treatment groups receiving Marchantia paleacea methanol extract designated as P1, P2, and P3, with dosages of 50, 150, and 150 mg/KgBW, respectively. The observations included the hematological analysis, the shape of breast nodules, and the histological examination of mammary glands. The analytical results indicate that the administration of Marchantia paleacea methanol extract considerably (p<0.05) has an effect on increasing the number of erythrocytes, leukoctys, hemoglobin, and hematocrit revealing a notable difference between the group receiving Marchantia paleacea liverwort extract and the negative control group. The observations of nodule morphology and histology in the intralobular and interlobular ducts reveal a significant difference (p<0.05), particularly between the negative control group and all liverwort extract treatment groups. The administration of 100 mg/kgBW is determined to be the most efficacious dosage, evidence by the enhancement of the blood profile, reduction in mammary nodule size, and the minimal tissue damage and severity scores.