Hubungan Vimentin dan Progesterone Receptor pada Grading Meningioma Menurut WHO di RS Kemenkes Haji Adam Malik Medan

Abstract

Background: Meningioma is the most common primary CNS tumor, with biological behavior linked to histopathological grade. Molecular markers such as vimentin and progesterone receptor (PR) may help assess tumor aggressiveness. Methods: This cross-sectional study included 30 meningioma patients who underwent surgery at Haji Adam Malik Hospital, Medan. Vimentin and PR expression were evaluated using immunohistochemistry and scored from +1 to +3. Spearman‟s test was used to analyze correlations with WHO grade. Results: Vimentin expression increased with tumor grade (r = +0.75, p < 0.001), while PR expression decreased (r = –0.68, p < 0.001). A combined profile of high vimentin and low PR predicted grade II–III tumors with 68.9% sensitivity and 65.4% specificity. Conclusion: Vimentin and PR expression are significantly correlated with WHO grading in meningioma. Their combined evaluation may assist in predicting tumor aggressiveness.