Pengaruh Pemberian Ekstrak Jamur Tiram (Pleurotus ostreatus) Terhadap Morfologi Dan Histologi Hati Tikus (Rattus norvegicus L.) Jantan Diberi Pakan Tinggi Lemak.

Abstract

High-fat diet can cause hyperlipidemia which causes to liver damage risk. This study aims to analyze the effect of oyster mushroom (Pleurotus ostreatus) extract on liver morphology and histology as well as liver enzyme levels Serum Glutamic Oxaloacetic Transaminase (SGOT) dan Serum Glutamic Pyruvic Transminase (SGPT) in male rats (Rattus norvegicus L.) fed by a high-fat diet. A total of 24 rats were divided into six treatment groups, including negative control, positive control (high-fat diet), and four treatment groups with simvastatin and oyster mushroom extract doses of 150, 300, and 450 mg/kgBW. The treatment was carried out for 42 days. The results show that oyster mushroom extract administration has a significant impact on the morphology and the weight of rat livers, and show significant improvement in the histological structure of hepatocytes (p<0.05), but there was no significant difference in SGOT and SGPT levels between groups. The optimal dose that show the best improvement in liver morphology and histology is 150 mg/kgBW. These results support the potential of oyster mushrooms as a hepatoprotective agent against liver damage due to high fat consumption.