Hubungan Pemberian ICS LABA terhadap Kadar Eosinofil Darah pada Penderita PPOK di Poliklinik RS USU

Abstract

Background and Aims: Blood eosinophil count may predict treatment response in patients with chronic obstructive pulmonary disease (COPD) during acute exacerbations. However, the ability of blood eosinophil counts in stable status to predict eosinophilic Methods: This was a cohort retrospective study performed Juni-August 2022 to Juni- August 2023. Subject were COPD patients who were treated at the outpatient using ICS LABA therapy. Blood samples measured blood eosinophil levels first and control. We identifed a blood eosinophil count cut-of point at stable COPD, as absolute value, for the relationship between ICS LABA Administration and Blood Eosinophil Levels in COPD Patient at Outpatient Clinic USU General Hospital. Results: It was found the Eosinophil before admission ICS had a median value 40.89 (0.00- 407.5) and Eosinophil after admission ICS had a median value 0.00 (0.00-65.67). There was signifcant positive correlation of eosinophil counts between ICS LABA Administration and Blood Eosinophil Levels in COPD Patient at Outpatient Clinic USU General Hospital Conclusion: We demonstrated association between ICS LABA Administration and Blood Eosinophil Levels in COPD Patient.