Hubungan Kadar Eosinofil Darah dengan Klasifikasi Asma Terkontrol pada Penderita Asma di Poliklinik Paru RS USU

Abstract

Introduction: Asthma is a heterogeneous disease with chronic airway inflammation characterized by symptoms like wheezing, shortness of breath, and coughing. Eosinophil infiltration distinguishes it from other airway inflammatory disorders, primarily triggered by allergen inhalation Objectives: To understand the relationship between blood eosinophil levels with exacerbation levels, shortness of breath levels, and hospitalization event in Asthma patients at the USU Hospital’s pulmonary polyclinic Methdos: Analytical observational research with a retrospective cohort approach and Mann- Whitney test to see the relationship between blood eosinophil levels with exacerbation levels, degree of shortness of breath, and hospitalization event in asthma patients. Samples are All outpatients with asthma aged over 18 years received ICS-LABA therapy and underwent peripheral blood eosinophil examinations at the USU Hospital’s pulmonary clinic for the period June–October 2023. Results: We received a total of 25 samples, the majority of which were female (80%), with eosinophil levels <100 (84%), patients never hospitalized (72%), and an age range of 26–50 years (44%). There was no correlation between eosinophil levels and exacerbation levels, shortness of breath levels, or hospitalization event among asthma patients at the USU Hospital pulmonary clinic. Conclusions: the rate of exacerbation, the degree of shortness of breath and hospitalization in asthma patients were not exclusively influenced by eosinophil levels. So, more research is needed on a number of other factors.