Hubungan Kadar Fibroblast Growth Factor-2 (FGF2) dengan Kejadian Tumor Mata

Abstract

Background: Ocular tumors are rare conditions that may pose a threat to vision and life. They encompass various types, including intraocular and extraocular tumors, which may be either benign or malignant. Fibroblast Growth Factor-2 (FGF2) is a potent pro-angiogenic factor suspected to play a critical role in tumor pathogenesis, including ocular tumors, due to its ability to stimulate tumor cell proliferation and neovascularization. Methods: This observational study employed a case-control design and was conducted at Prof. Dr. Chairuddin P. Lubis Hospital, Universitas Sumatera Utara, and its affiliated network hospitals. Study subjects consisted of patients diagnosed with ocular tumors (both benign and malignant) and healthy controls. Serum levels of FGF2 were measured using the ELISA method. Statistical analyses were performed using SPSS software version 24.0. Results: A total of 38 patients were included in the study, with 65.8% being female. The mean age of participants was within the fifth decade of life. FGF2 levels were significantly higher in the tumor group compared to the control group (p = 0.04). Furthermore, FGF2 levels were significantly elevated in patients with malignant tumors compared to those with benign tumors (p = 0.001), indicating a correlation between elevated FGF2 levels and tumor malignancy. Conclusion: There is a significant association between FGF2 levels and the occurrence of ocular tumors. FGF2 also has potential as a biomarker to differentiate between benign and malignant ocular tumors.