Efek Irigasi Hidung dengan Madu sebagai Terapi Adjuvan pada Rinosinusitis Kronis Primer Pascaoperasi Bedah Sinus Endoskopik Fungsional

Abstract

Introduction: Many patients continue to experience symptoms of chronic rhinosinusitis (CRS) despite receiving the most intensive topical and surgical treatments. Honey has various properties, such as antimicrobial, antioxidant, healing, and anti-inflammatory effects, which potentially reduce dependence on antibiotics and steroids in managing CRS.

Objective: This study aims to investigate the effect of nasal irrigation with a standardized honey solution on the healing of the nasal and paranasal sinus mucosa after undergoing functional endoscopic sinus surgery.

Methods: This prospective randomized controlled experimental study recruited patients with primary CRS who had previously undergone sinus surgery. Patients received sinus irrigation with either honey or 0.9% NaCl twice daily for 30 days and were given oral antibiotics and/or oral/topical steroids as indicated. Outcomes measured were changes in Sino-Nasal Outcome Test-22 (SNOT-22) scores and Lund-Kennedy endoscopic change scores on days 3, 7, 14, and 30 postoperatively.

Results: Thirty-two patients were analyzed (Honey, n = 16; 0.9% NaCl, n = 16). The change in SNOT-22 scores showed clinically significant improvement in both groups, but was similar between the honey and 0.9% NaCl groups (p = 0.215). The Lund-Kennedy endoscopic change scores improved in both groups and were significantly better in the honey group (p = 0.007). No side effects were reported.

Conclusion: Nasal irrigation with honey was well tolerated. Preliminary data indicate that honey provides a clinically important difference in quality-of-life scores and significantly better endoscopic outcomes. For a future definitive trial, multi-institutional recruitment would be required.